Factores preditivos da mucosite oral induzida por quimioterapia no cancro colorrectal: papel dos polimorfismos nos genes que medeiam a resposta inflamatória

Autores

Catarina Rodrigues Serviço de Oncologia Médica - Centro Oncológico, CHTMAD, EPE
Carina Pereira Universidade do Porto, Porto
Rui Medeiros Universidade do Porto, Porto
Mário Dinis-Ribeiro C.I.N.T.E.S.I.S. – Serviço de Bioestatística e Informática Médica. Faculdade de Medicina do Porto, Porto

DOI:

https://doi.org/10.31877/on.2010.14.02

Palavras-chave:

Mucosite oral, polimorfismos genéticos, cancro colorectal, quimioterapia, inflamação

Resumo

A partir de uma série consecutiva de doentes oncológicos com cancro colorrectal submetidos a quimioterapia (n=108), foi realizado um estudo de caso-controlo de forma a determinar o papel dos polimorfismos genéticos nos genes que medeiam a resposta inflamatória no processo de evolução da mucosite oral. Foram ainda incluídas outras variáveis para estudo, capazes de influenciar o risco individual para desenvolver este efeito secundário. Contudo, não foram identificadas quaisquer divergências entre géneros, idade média dos participantes, índice de massa corporal, diabetes mellitus, prótese dentária, hábitos tabágicos e alcoólicos e alterações hematológicas nos grupos caso e controlo. A mucosite oral prévia foi identificada numa grande proporção de casos (35%)
(vs 0% no grupo controlo, p≤0.001). Os portadores do alelo A na posição -308G>A no gene TNF-α (genótipos GA e AA) possuem um risco diminuído para desenvolver a mucosite oral (OR=0.266; 95%IC: 0.073-0.964) após os tratamentos de quimioterapia específicos para cancro colorrectal.
Para que se possam estabelecer medidas profiláticas e realizar diagnósticos precoces da mucosite oral em indivíduos com cancro colorrectal submetidos a quimioterapia serão necessários estudos ulteriores que incluam os factores preditivos identificados.

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Publicado

10-09-2010

Como Citar

Rodrigues C, Pereira C, Medeiros R, Dinis-Ribeiro M. Factores preditivos da mucosite oral induzida por quimioterapia no cancro colorrectal: papel dos polimorfismos nos genes que medeiam a resposta inflamatória. journal [Internet]. 10 de Setembro de 2010 [citado 16 de Maio de 2024];(14):18-25. Disponível em: https://onco.news/index.php/journal/article/view/221